Laboratory of Integrative Cancer Immunology

Director : 

Jérôme Galon

We aim to understand tumor progression and immune reaction against cancer from pre-cancerous lesion to metastasis by using integrative biology and bioinformatics, to improve the immunotherapeutic management of cancer patients. Our research projects are focusing on the analysis of the pre-existing immunity and its modulation.

Key Words: Tumor, Immune, Bioinformatics, Integration

Immunoscore quantification. CD3 chromogenic staining on colorectal tumor tissue by IHC.(left).Characterization of the tumor immune microenvironment. Multiplexed imaging of colorectal tumor tissue: DAPI (blue), CD3 (green), CD8 (red), FoxP3 (yellow), Neutrophil elastase (white), CD68 (magenta) and Cytokeratin (cyan) (right)

 

Comparison tumor vs normal colon tissue. CyTOF analysis – Clustering using UMAP

Main publications

Mlecnik B, Bifulco C, Bindea G, Marliot F, Lugli A, Lee JJ, Zlobec I, Rau TT, Berger MD, Nagtegaal ID, Vink-Börger E, Hartmann A, Geppert C, Kolwelter J, Merkel S, Grützmann R, Van den Eynde M, Jouret-Mourin A, Kartheuser A, Léonard D, Remue C, Wang JY, Bavi P, Roehrl MHA, Ohashi PS, Nguyen LT, Han S, MacGregor HL, Hafezi-Bakhtiari S, Wouters BG, Masucci GV, Andersson EK, Zavadova E, Vocka M, Spacek J, Petruzelka L, Konopasek B, Dundr P, Skalova H, Nemejcova K, Botti G, Tatangelo F, Delrio P, Ciliberto G, Maio M, Laghi L, Grizzi F, Fredriksen T, Buttard B, Lafontaine L, Bruni D, Lanzi A, El Sissy C, Haicheur N, Kirilovsky A, Berger A, Lagorce C, Paustian C, Ballesteros-Merino C, Dijkstra J, van de Water C, van Lent-van Vliet S, Knijn N, Muşină AM, Scripcariu DV, Popivanova B, Xu M, Fujita T, Hazama S, Suzuki N, Nagano H, Okuno K, Torigoe T, Sato N, Furuhata T, Takemasa I, Itoh K, Patel PS, Vora HH, Shah B, Patel JB, Rajvik KN, Pandya SJ, Shukla SN, Wang Y, Zhang G, Kawakami Y, Marincola FM, Ascierto PA, Fox BA, Pagès F, Galon J*.
Multicenter International Society for Immunotherapy of Cancer Study of the Consensus Immunoscore for the Prediction of Survival and Response to Chemotherapy in Stage III Colon Cancer.
J Clin Oncol. 2020 Sep 8:JCO1903205.

Pagès F, André T, Taieb J, Vernerey D, Henriques J, Borg C, Marliot F, Ben Jannet R, Louvet C, Mineur L, Bennouna J, Desrame J, Faroux R, Kirilovsky A, Duval A, Laurent-Puig P, Svrcek M, Hermitte F, Catteau A, Galon J*, Emile JF*.
Prognostic and predictive value of the Immunoscore in stage III colon cancer patients treated with oxaliplatin in the prospective IDEA France PRODIGE-GERCOR cohort study.
Ann Oncol. 2020 Apr 12:S0923-7534(20)36415-2.

Galon J*, Bruni D.Tumor Immunology and Tumor Evolution: Intertwined Histories. Immunity, 2020 Jan 14, 52 (1), 55-81

Bruni D, Angell HK, Galon J*. The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy. Nat Rev Cancer. 2020 Nov;20(11):662-680.

All publications

Fundings