Metabolic Diseases, Diabetes and co-morbidities

Director : 

Fabienne Foufelle

Deputy Director : 

Frédéric Jaisser

We  study in animal models and through clinical studies the co-morbidities associated with diabetes and obesity such as Non-Alcoholic Fatty Liver, cardiovascular and chronic kidney diseases, that strongly impact morbidity and mortality worldwide.

 

Keywords : Type 2 diabetes, obesity, metabolic liver disease, insulin resistance, kidney disease, mineralocorticoid receptor

Scientific Themes

Non Alcoholic Fatty liver diseases and type 2 diabetes

We study the mechanisms leading to Non-Alcoholic Fatty Liver and its complications associated with diabetes and obesity in animal models and in clinical studies.

Mineralocorticoid Receptor : role in renal and metabolic co-morbidities and therapeutic implications

We aim at improving the understanding of the pathophysiological roles and signaling pathways whereby the mineralocorticoid receptor (MR) promotes pathologies.

Role of sphingolipid metabolism in the development of type 2 diabetes

We study the molecular mechanisms involved in insulin resistance induced by fatty acid derivatives, such as ceramide, in insulin sensitive tissues.

Main publications

Carlier A, Phan F, Szpigel A, Hajduch E, Salem JE, Gautheron J, Le Goff W, Guérin M, Lachkar F, Ratziu V, Hartemann A, Ferré P, Foufelle F, Bourron O. Dihydroceramides in Triglyceride-Enriched VLDL Are Associated with Nonalcoholic Fatty Liver Disease Severity in Type 2 Diabetes.Cell Rep Med. 2020 Dec 22;1(9):100154. doi: 10.1016/j.xcrm.2020.100154. eCollection 2020 Dec 22. PMID: 33377125

Zhao M, Mantel I, Gelize E, Li X, Xie X, Arboleda A, Seminel M, Levy-Boukris R, Dernigoghossian M, Prunotto A, Andrieu-Soler C, Rivolta C, Canonica J, Naud MC, Lechner S, Farman N, Bravo-Osuna I, Herrero-Vanrell R, Jaisser F, Behar-Cohen F. Mineralocorticoid receptor antagonism limits experimental choroidal neovascularization and structural changes associated with neovascular age-related macular degeneration. Nat Commun. 2019 Jan 21;10(1):369. PMID: 30664640

Lefranc C, Friederich-Persson M, Braud L, Palacios-Ramirez R, Karlsson S, Boujardine N, Motterlini R, Jaisser F, Nguyen Dinh Cat A. MR (Mineralocorticoid Receptor) Induces Adipose Tissue Senescence and Mitochondrial Dysfunction Leading to Vascular Dysfunction in Obesity. Hypertension. 2019 Feb;73(2):458-468. PMID: 30624990

Barrera-Chimal J, Estrela GR, Lechner SM, Giraud S, El Moghrabi S, Kaaki S, Kolkhof P, Hauet T, Jaisser F. The myeloid mineralocorticoid receptor controls inflammatory and fibrotic responses after renal injury via macrophage interleukin-4 receptor signaling. Kidney Int. 2018 Jun;93(6):1344-1355. doi: 10.1016/j.kint.2017.12.016. Epub 2018 Mar 13. PMID: 29548765

Bandet CL, Mahfouz R, Véret J, Sotiropoulos A, Poirier M, Giussani P, Campana M, Philippe E, Blachnio-Zabielska A, Ballaire R, Le Liepvre X, Bourron O, Berkeš D, Górski J, Ferré P, Le Stunff H, Foufelle F, Hajduch E. Ceramide Transporter CERT Is Involved in Muscle Insulin Signaling Defects Under Lipotoxic Conditions. Diabetes. 2018 Jul;67(7):1258-1271. PMID: 29759974

Szpigel A, Hainault I, Carlier A, Venteclef N, Batto AF, Hajduch E, Bernard C, Ktorza A, Gautier JF, Ferré P, Bourron O, Foufelle F. Lipid environment induces ER stress, TXNIP expression and inflammation in immune cells of individuals with type 2 diabetes. Diabetologia. 2018 Feb;61(2):399-412. PMID: 28988346

Cariou B, Hadjadj S, Wargny M, Pichelin M, Al-Salameh A, Allix I, Amadou C, Arnault G, Baudoux F, Bauduceau B, Borot S, Bourgeon-Ghittori M, Bourron O, Boutoille D, Cazenave-Roblot F, Chaumeil C, Cosson E, Coudol S, Darmon P, Disse E, Ducet-Boiffard A, Gaborit B, Joubert M, Kerlan V, Laviolle B, Marchand L, Meyer L, Potier L, Prevost G, Riveline JP, Robert R, Saulnier PJ, Sultan A, Thébaut JF, Thivolet C, Tramunt B, Vatier C, Roussel R, Gautier JF, Gourdy P. Phenotypic characteristics and prognosis of inpatients with COVID-19 and diabetes: the CORONADO study. Diabetologia. 2020 Aug;63(8):1500-1515. doi: 10.1007/s00125-020-05180-x. PMID: 32472191

All publications

Fundings