Metabolic Diseases, Diabetes and co-morbidities
Director :
Fabienne Foufelle
Deputy Director :
Frédéric Jaisser
We study in animal models and through clinical studies the co-morbidities associated with diabetes and obesity such as Non-Alcoholic Fatty Liver, cardiovascular and chronic kidney diseases, that strongly impact morbidity and mortality worldwide.
Keywords : Type 2 diabetes, obesity, metabolic liver disease, insulin resistance, kidney disease, mineralocorticoid receptor
Scientific Themes
Non Alcoholic Fatty liver diseases and type 2 diabetes
We study the mechanisms leading to Non-Alcoholic Fatty Liver disease and its complications, which are both strongly associated with diabetes and obesity..
Mineralocorticoid Receptor : role in renal and metabolic co-morbidities and therapeutic implications
We aim at improving the understanding of the signaling pathways whereby the mineralocorticoid receptor (MR) exerts its pathophysiological roles.
Role of sphingolipid metabolism in the development of type 2 diabetes
We study the molecular mechanisms involved in insulin resistance induced by fatty acid derivatives, such as ceramides, in insulin sensitive tissues.
Main publications
Benefits of the Non-Steroidal Mineralocorticoid Receptor Antagonist Finerenone in Metabolic Syndrome-Related Heart Failure with Preserved Ejection Fraction. Lima-Posada I, Stephan Y, Soulié M, Palacios-Ramirez R, Bonnard B, Nicol L, Kolkhof P, Jaisser F, Mulder P. Int J Mol Sci. 2023 Jan 28;24(3):2536. doi: 10.3390/ijms24032536. PMID: 36768859; PMCID: PMC9916671. link
The myeloid mineralocorticoid receptor regulates dermal angiogenesis and inflammation in glucocorticoid-induced impaired wound healing. Nguyen VT, Ngo QT, Ramirez RP, Nakamura T, Farman N, Aractingi S, Jaisser F. Br J Pharmacol. 2022 Dec;179(23):5222-5232. doi: 10.1111/bph.15932. Epub 2022 Sep 2. PMID: 35861949; PMCID: PMC9826027. link
Mineralocorticoid Receptor Antagonism Prevents the Synergistic Effect of Metabolic Challenge and Chronic Kidney Disease on Renal Fibrosis and Inflammation in Mice. Palacios-Ramirez R, Lima-Posada I, Bonnard B, Genty M, Fernandez-Celis A, Hartleib-Geschwindner J, Foufelle F, Lopez-Andres N, Bamberg K, Jaisser F. Front Physiol. 2022 Apr 7;13:859812. doi: 10.3389/fphys.2022.859812. PMID: 35464084; PMCID: PMC9022039. link
Neutrophil Gelatinase-Associated Lipocalin From Macrophages Plays a Critical Role in Renal Fibrosis Via the CCL5 (Chemokine Ligand 5)-Th2 Cells-IL4 (Interleukin 4) Pathway Bonnard B, Ibarrola J, Lima-Posada I, Fernández-Celis A, Durand M, Genty M, Lopez-Andrés N, Jaisser F. Hypertension. 2022 Feb;79(2):352-364. doi: 10.1161/HYPERTENSIONAHA.121.17712. Epub 2021 Nov 19. PMID: 34794340. link
Adipocyte-Mineralocorticoid Receptor Alters Mitochondrial Quality Control Leading to Mitochondrial Dysfunction and Senescence of Visceral Adipose Tissue. Lefranc C, Friederich-Persson M, Foufelle F, Nguyen Dinh Cat A, Jaisser F. Int J Mol Sci. 2021 Mar 12;22(6):2881. doi: 10.3390/ijms22062881. PMID: 33809055; PMCID: PMC8001019. link
Antifibrotic effect of novel neutrophil gelatinase-associated lipocalin inhibitors in cardiac and renal disease models. Bonnard B, Martínez-Martínez E, Fernández-Celis A, Pieronne-Deperrois M, Do QT, Ramos I, Rossignol P, Zannad F, Mulder P, Ouvrard-Pascaud A, López-Andrés N, Jaisser F. Sci Rep. 2021 Jan 28;11(1):2591. doi: 10.1038/s41598-021-82279-0. PMID: 33510370; PMCID: PMC7844219. link
Ceramide analog C2-cer induces a loss in insulin sensitivity in muscle cells through the salvage/recycling pathway. Bandet CL, Tan-Chen S, Ali-Berrada S, Campana M, Poirier M, Blachnio- Zabielska A, Pais-de-Barros JP, Rouch C, Ferré P, Foufelle F, Le Stunff H, Hajduch E. J Biol Chem. 2023 May 11;299(6):104815. doi: 10.1016/j.jbc.2023.104815. Epub ahead of print. PMID: 37178918; PMCID: PMC10276168. link
All publications
