Metabolism, Cancer and Immunity

Director : 

Guido Kroemer

The team is interested in the triangulation between metabolism (with emphasis on metabolic syndrome, obesity and nutrition), cancer (especially the common cancers: colon, lung and breast) and immunity (and the link between anti-cancer immunosurveillance and autoimmunity) by following the arrow of time, aging

 

Effective treatment of imaging-diagnosed lung cancer (blue areas, then red as cancers progress) following combinatorial therapy involving immunotherapy (anti-PD-1 and anti-CTLA-4), chemotherapy (cisplatin, CDDP) and targeted therapy (with (R)-Crizotinib). Peng et al. Nature Communications 2019.

Main publications

Liu P, Zhao L, Pol J, Levesque S, Petrazzuolo A, Pfirschke C, Engblom C, Rickelt S, Yamazaki T, Iribarren K, Senovilla L, Bezu L, Vacchelli E, Sica V, Melis A, Martin T, Lin X, Yang H, Li Q, Chen J, Durand S, Aprahamian F, Lefevre D, Broutin S, Paci A, Bongers A, Minard-Colin V, Tartour E, Zitvogel L, Apetoh L, Ma Y, Pittet MJ, Kepp O, Kroemer G. Crizotinib-induced immunogenic cell death in  non-small cell lung cancer. Nat Commun. 2019 Apr 2;10(1):1486.

Bravo-San Pedro JM, Sica V, Martins I, Pol J, Loos F, Maiuri MC, Durand S, Bossut N, Aprahamian F, Anagnostopoulos G, Niso-Santano M, Aranda F, Ramírez-Pardo I, Lallement J, Denom J, Boedec E, Gorwood P, Ramoz N, Clément K, Pelloux V, Rohia A, Pattou F, Raverdy V, Caiazzo R, Denis RGP, Boya P, Galluzzi L, Madeo F, Migrenne-Li S, Cruciani-Guglielmacci C, Tavernarakis N, López-Otín C, Magnan C, Kroemer G. Acyl-CoA-binding protein is a lipogenic factor that triggers food intake and obesity. Cell Metab. 2019 Sep 3;30(3):462-476.

Yang H, Xia L, Chen J, Zhang S, Martin V, Li Q, Lin S, Chen J, Calmette J, Lu M, Fu L, Yang J, Pan Z, Yu K, He J, Morand E, Schlecht-Louf G, Krzysiek R, Zitvogel L, Kang B, Zhang Z, Leader A, Zhou P, Lanfumey L, Shi M, Kroemer G*, Ma Y. (*Corresponding author). Stress-glucocorticoid-TSC22D3 axis compromises therapy-induced antitumor immunity. Nat Med. 2019 Sep;25(9):1428-1441.

Zhao L, Liu P, Loos F, Marty C, Xie W, Martins I, Lachkar S, Qu B, Waeckel-Enee E, Plo I, Perez F, Lopez-Otin C, van Endert P, Zitvogel L, Kepp O, Kroemer G. Immunosuppression by mutated calreticulin released from malignant cells. Mol Cell. 2020 Feb 20;77 (4), 748-760.e9s.

Humeau JF, Sauvat A, Cerrato G, Loos F, Ianntuoni F, Bezu L, Levesque S, Paillet J, Pok J, Stoll G, Leduc M, Zitvogel L, de Thé H, Kepp O, Kroemer G. Immunogenic cancer cell stress involves inhibition of transcription. EMBO Mol Med. 2020 Apr 23:e11622.

All publications