Proliferation stress and liver physiopathology (ProLiverPP)

Brief history of the team
The team directed by Chantal Desdouets was created in January 2014. It is affiliated to INSERM (Institut National de la Santé Et de la Recherche Médicale) and Université de Paris.
Chantal Desdouets is Research Director at INSERM. She has a long-standing experience in the study of cell cycle control in mammals system. She is a pioneer on liver polyploidy topic. She is a member of the Editorial Board of the Journal JHEP Reports. Since January 2019, she is the Co-Director of BioSPC Doctoral School at Université de Paris.
Other talented researchers joined the laboratory. Jean Pierre Couty, Associate Professor at Université de Paris, is teaching Immunology and cell biology. He is an expert in the field of immune microenvironment during liver cancer development. Séverine Celton-Morizur, INSERM Researcher has a strong experience in the domain of mitotic checkpoints and DNA integrity. Based on our complementary scientific expertise, control of hepatocyte division is the common thread of our projects. Since 2019, the Team decided to join the Centre de Recherche des Cordeliers as an opportunity to develop ambitious multidisciplinary projects exploring notably the links between cell proliferation metabolism-immune-microenvironment and liver tumorigenesis.

Our Expertise

  • Polyploidy, cell cycle, DNA damage, metabolism, immune microenvironment and liver cancer
  • Animal models (NAFLD and HCC mouse models), virtual slides pathology, primary hepatocytes culture, liver regeneration (partial hepatectomy, paracetamol overload).
  • Cell/molecular biology (proliferation, cell cycle, DNA damage, immune cell flow cytometry and FAC sorting, gene expression, CRISPR), RNA seq.
  • Cell imaging in situ immunostaining, fluorescence, multispectral, confocal).