Functional Genomics of Solid Tumors (FUNGEST)

Director : 

Jessica Zucman-Rossi

Deputy Director : 

Didier Jean


We develop translational genomic approaches based on human tumors analyses to identify new mechanisms of tumorigenesis (e.g. new genomic alterations, clinical/genomic risk factors) and to propose biomarkers and therapeutic targets that could be introduced in clinical practice. Our general strategy is based on the large-scale genomic analysis of large cohorts of patients with liver tumors (benign and malignant), mesothelioma and renal cancer. The team is organized in 4 groups with their projects:

Scientific Themes

Functional Genomics of Liver and Renal Tumors

Focused on the characterization and functional validation of genomic alterations in benign and malignant liver tumors, identification of new clinical/genomic risk factors, and ultimately, translation to the clinics.

Computational Cancer Genome Analysis

Develops innovative strategies for integrative genomic data analysis in order to decipher the interaction between clinical risk factors, endogenous cellular processes and genomic alterations in liver carcinogenesis.

Therapeutic Targets in liver tumors

Develops an integrated approach that extends from the study of the molecular basis of tumor initiation and progression to applications of targeted treatment and the identification of biomarkers predicting the therapeutic response.

Functional Genomics of Mesothelioma

studies pathogenesis of malignant pleural mesothelioma (MPM), a rare tumor, with poor prognosis due to the lack of efficient treatment.

Main publications

RSK2 inactivation cooperates with AXIN1 inactivation or ß-catenin activation to promote hepatocarcinogenesis. Samantha Schaeffer, Barkha Gupta, Anna-Line Calatayud, Julien Calderaro, Stefano Caruso, Théo Z Hirsch, Laura Pelletier, Jessica Zucman-Rossi, Sandra Rebouissou. Journal of hepatology 2023 link

Common genetic variation in alcohol-related hepatocellular carcinoma: a case-control genome-wide association study. Eric Trépo, Stefano Caruso, Jie Yang, Sandrine Imbeaud, Gabrielle Couchy, Quentin Bayard, Eric Letouzé, Nathalie Ganne-Carrié, Christophe Moreno, Abderrahim Oussalah, Cyrille Féray, Jean Frédéric Blanc, Bruno Clément, Patrick Hillon, Jérôme Boursier, Valérie Paradis, Julien Calderaro, Viviane Gnemmi, Jean-Charles Nault, Jean-Louis Guéant, Jacques Devière, Isabelle Archambeaud, Carole Vitellius, Bruno Turlin, Jean-Pierre Bronowicki, Thierry Gustot, Angela Sutton; GENTHEP Consortium; Marianne Ziol , Pierre Nahon , Jessica Zucman-Rossi. The Lancet Oncology 2022 link

Hepatitis B virus integrations promote local and distant oncogenic driver alterations in hepatocellular carcinoma. Camille Péneau, Sandrine Imbeaud, Tiziana La Bella, Theo Z Hirsch, Stefano Caruso, Julien Calderaro, Valerie Paradis, Jean-Frederic Blanc, Eric Letouzé, Jean-Charles Nault, Giuliana Amaddeo, Jessica Zucman-Rossi. Gut 2022. link

Telomere length is key to hepatocellular carcinoma diversity and telomerase addiction is an actionable therapeutic target. Massih Ningarhari, Stefano Caruso, Théo Z Hirsch, Quentin Bayard, Andrea Franconi, Anne-Laure Védie, Bénédicte Noblet, Jean-Frédéric Blanc, Giuliana Amaddeo, Nathalie Ganne, Marianne Ziol, Valérie Paradis, Catherine Guettier, Julien Calderaro, Guillaume Morcrette, Youngsoo Kim, A Robert MacLeod, Jean-Charles Nault, Sandra Rebouissou, Jessica Zucman-Rossi. Journal of hepatology 2021 link

Integrated Genomic Analysis Identifies Driver Genes and Cisplatin-Resistant Progenitor Phenotype in Pediatric Liver Cancer. Theo Z Hirsch, Jill Pilet, Guillaume Morcrette, Amélie Roehrig, Benedict J E Monteiro, Laura Molina, Quentin Bayard, Eric Trépo, Léa Meunier, Stefano Caruso, Victor Renault, Jean-François Deleuze, Brice Fresneau, Christophe Chardot, Emmanuel Gonzales, Emmanuel Jacquemin, Florent Guerin, Monique Fabre, Isabelle Aerts, Sophie Taque, Véronique Laithier, Sophie Branchereau, Catherine Guettier, Laurence Brugières, Sandra Rebouissou, Eric Letouzé, Jessica Zucman-Rossi. Cancer discovery 2021 link

DNA Methylation Signatures Reveal the Diversity of Processes Remodeling Hepatocellular Carcinoma Methylomes. Léa Meunier, Théo Z Hirsch, Stefano Caruso, Sandrine Imbeaud, Quentin Bayard, Amélie Roehrig, Gabrielle Couchy, Jean-Charles Nault, Josep M Llovet, Jean-Frédéric Blanc, Julien Calderaro, Jessica Zucman-Rossi, Eric Letouzé. Hepatology 2021 link

Adeno-associated virus in the liver: natural history and consequences in tumour development. Tiziana La Bella, Sandrine Imbeaud, Camille Peneau, Iadh Mami, Shalini Datta, Quentin Bayard, Stefano Caruso, Theo Z Hirsch, Julien Calderaro, Guillaume Morcrette, Catherine Guettier, Valerie Paradis, Giuliana Amaddeo, Alexis Laurent, Laurent Possenti, Laurence Chiche, Paulette Bioulac-Sage, Jean-Frederic Blanc, Eric Letouze, Jean-Charles Nault, Jessica Zucman-Rossi. Gut 2020 link

Clinical Impact of Genomic Diversity From Early to Advanced Hepatocellular Carcinoma. Jean-Charles Nault, Yoann Martin, Stefano Caruso, Théo Z Hirsch, Quentin Bayard, Julien Calderaro, Cecile Charpy, Christiane Copie-Bergman, Marianne Ziol, Paulette Bioulac-Sage, Gabrielle Couchy, Jean-Frédéric Blanc, Pierre Nahon, Giuliana Amaddeo, Nathalie Ganne-Carrie, Guillaume Morcrette, Laurence Chiche, Christophe Duvoux, Sandrine Faivre, Alexis Laurent, Sandrine Imbeaud, Sandra Rebouissou, Josep M Llovet, Olivier Seror, Eric Letouzé, Jessica Zucman-Rossi. Hepatology 2020 link

All publications